Generic Name: Diazepam Rectal Gel (di-AZ-e-pam)
Used to Treat: epilepsy
Seizure Type: All seizure types
Forms of the medicine:
0.2 mg. - 0.5 mg./kg.
What is Diastat AcuDial?
Diastat AcuDial is a brand of the generic drug diazepam rectal gel. It is a gel preparation of diazepam for rectal administration for the treatment of serial or cluster seizures, sometimes referred to as acute repetitive seizures. Diastat works to stop seizure activity by acting on brain cell interactions that inhibit the seizure impulses. Diastat is rapidly absorbed from the lining of the rectum and quickly achieves therapeutic levels in the serum. It can be used in children and adults.
How do I use Diastat AcuDial?
Be sure to follow caregiver’s instruction. Diastat AcuDial is administered through a rectal tipped syringe prepared with the appropriate dose. It may be administered by parents / caregivers under specific instructions given by the healthcare provider. A prescription is required to obtain this medication as well as the necessary equipment including syringes. One box contains two doses (2 syringes), lubricating jelly and patient/caregiver information.
The dose will be prescribed by the treating physician, based on age and weight of the patient. Administration during a seizure should be discussed and decided with the treating physician. A second dose may be given within 4-12 hours after the first dose if seizures persist or return. Diastat should not be given more frequently than every five days and no more than five times per month. The dosage may need to be readjusted when there are changes in weight or growth.
Diastat is not intended to be used as a daily medication. Tolerance to the medication can develop when used chronically. Increases in frequency and severity of tonic-clonic (grand mal) seizures may occur with daily use.
What if I miss a dose?
Administer the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue the regular dosing schedule. Do not administer an extra dose, unless prescribed by the doctor.
What if I experience side effects?
The most common side effect of Diastat AcuDial is sleepiness. Other less frequent side effects include skin rash, dizziness, pain, headache, stuffy nose, abdominal pain, nervousness, diarrhea, feeling unsteady or clumsy, and wheezing. You or your caregiver should tell your doctor about any side effects that you experience.
Call a doctor right away if these side effects become severe or cause considerable problems in your daily functions. If you experience a change in seizures, severe rash, or allergic reaction contact your doctor immediately.
Contact your physician immediately if you experience any of the following side effects:
Keep this medication in its original container, tightly closed, and out of reach of children. Store the prescription at room temperature, away from excess heat and moisture (i.e. not the bathroom). Do not freeze the gel. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Recommendation for women
Diastat Acudial can cross the placenta and levels have been found in cord blood. Diastat levels have also been found in breast milk for some time after administration. It is recommended that mothers refrain from breast feeding for several hours after receiving Diastat.
Other helpful information
There are some drugs that may enhance the effects of the Diastat; these drugs include phenothiazines, narcotics, barbiturates, MAO inhibitors and antidepressants. Valproate may also enhance the depressant effect of the Diastat. There are some potential drug-drug interactions that might take place as Diastat metabolism shares common pathways with other drugs. If symptoms develop that are unusual for the patient, these should be reported to the treating physician. Notify your doctor if you have history of prior adverse effect from diazepam or Diastat.
Behavior changes, Sleepiness, Unsteadiness, Drowsiness, Fatigue, Poor coordination, Upset stomach, Insomnia, Confusion, Nervousness, Dizziness