Manufactured by Eisai


Generic Name: Zonisamide (zo-NIS-I-mide)

Used to Treat: epilepsy

Seizure Type: Simple partial

Forms of the medicine:

100 mg. - 600 mg.

General Info:
What is Zonegran?
Zonegran (ZAHN-uh-gran) is the brand name for the generic seizure medicine zonisamide (zoh-NIH-sah-mide). Zonegran is primarily is used in combination with other medications to treat the adults experiencing partial seizures. It works by decreasing abnormal excitement in the brain. It is available in 25, 50, and 100 mg capsules.

How do I take Zonegran?
Take this medication exactly as it is prescribed for you. Do not take the medication in larger amounts or longer than recommended by your doctor. Do not change your dosage without your doctor's advice. Tell your doctor if the medication does not seem to work in treating your condition.

Zonegran may or may not be taken with food depending on your tendency for upset stomach. However, do try to take in the same manner and at the same time every day. Do not open, chew, or crush the capsules; swallow them whole. It is recommended to drink plenty of water when taking this medication as it has been known to cause kidney stones. Usually, your doctor will tell you to start by taking no more than 100 mg each day. After a while the doctor may tell you to take a larger dose to get better control of your seizures. Usually the doctor will tell you to take all the capsules at one time, or perhaps to take capsules twice a day.

What if I miss a dose?
Take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take an extra dose, unless prescribed by your doctor.

What if I experience side effects?
Various side effects may occur in taking this medicine. Most side effects are not serious and may disappear naturally. Call your doctor if you have any questions concerning your possible side effects. However, do not stop taking your medication without advice from your doctor. They will discuss and recommend possible options. At times it is necessary to continue taking your medication despite these side effects.

There are other side effects that may be serious and indicate that your body is not tolerating the drug properly. Call a doctor right away if these side effects become severe or cause considerable problems in your daily functions. If you experience a change in seizures, severe rash, or allergic reaction contact your doctor immediately as these may indicate potentially life threatening problems.

Contact your physician immediately if you experience any of the following side effects:

  • Rash
  • Worsening or longer lasting seizures
  • Sudden back pain
  • Stomach pain
  • Pain when urinating
  • Bloody or dark urine
  • Fever
  • Sore throat
  • Easy bruising
  • Depression/Suicidal thinking
  • Unusual thoughts
  • Difficulty thinking of words or trouble speaking
  • Difficulty walking

Keep this medication in its original container, tightly closed, and out of reach of children. Store your prescription at room temperature, away from excess heat and moisture (i.e. not the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Recommendation for women
Zonegran has an FDA pregnancy category of “C” meaning that the benefits of the medicine may outweigh the risks of harming the fetus. Women who are taking this medication and who wish to become pregnant should discuss treatment options with their physicians before the pregnancy begins.

Other helpful information
Doctors may use Zonegran for the conditions like Lennox-Gastaut syndrome, infantile spasms, and progressive myoclonic epilepsy. Discuss with your physician if you are using Zonegran for the above conditions.

Side Effects

Nausea, Rash, Difficulty concentrating, Irritability, Dizziness, Headaches, Sleepiness, Appetite loss, Confusion, Numbness of extremities